;-------------------------------------------------------------
; Data     : Michaelis & Menten (1913) Table I
;-------------------------------------------------------------

[task]

   data = progress
   task = fit
   model = plain ?

[mechanism]

   E + S <==> ES    : k   ks    
   ES --> E + P     : kr

[constants]

   k  = 100
   ks = 10000 ?   
   kr = 100 ?
   
[responses]

   S =  0.0425
   P = -0.0133

[progress]

   directory  ./examples/invertase/data
   extension  txt
   
   file s5    | conc. S =   5.2 ?, E = 0.01
   file s10   | conc. S =  10.4 ?, E = 0.01 ?
   file s21   | conc. S =  20.8 ?, E = 0.01 ?
   file s42   | conc. S =  41.6 ?, E = 0.01 ?
   file s83a  | conc. S =  83.2 ?, E = 0.01 ?
   file s83b  | conc. S =  83.2 ?, E = 0.01 ?
   file s166  | conc. S = 166.5 ?, E = 0.01 ?
   file s333  | conc. S = 333.0 ?, E = 0.01 ?

[output]

   directory  ./examples/invertase/output/models

[settings]

   <Marquardt>   | Interrupt  = 300
   <Filter>      | SetSigZero = no

;-------------------------------------------------------------

[task]

   data = progress
   task = fit
   model = inhibit ?

[mechanism]

   E + S <==> ES    : k   ks    
   ES --> E + P     : kr
   E + P <==> EP    : k   kp

[constants]

   k  = 10000
   ks = 1000000 ?, kp = 10000000 ?    
   kr = 100 ?
   
[end]