The King-Altman method [1] has been implemented as an interactive web form. The user can type a reaction mechanism in a symbolic form, using the usual chemical notation (e.g., E + S <==> ES ---> E + P) and obtain the result in the algebraic form.

The present implementation of the King-Altman method was inspired by a discussion presented by Cornish-Bowden [2]. All test examples were gathered from an enzyme kinetic textbook by Segel's [3].

Data Submission Form

Use this form to submit a mechanism in the symbolic form to derive the corresponding steady-state rate equation.

Examples

A list of example problems that were used for testing. Copy a given mechanisms and paste it into the data submission form.

Theory

A few notes on the motivation for this tool and on its design (for example, why does the online form not produce Michaelis constants).

References

1. King, E. L. and Altman, C. (1956) "A Schematic Method of Deriving the Rate Laws for Enzyme-Catalyzed Reactions" J. Phys. Chem. 60, 1375-1378.
2. Cornish-Bowden, A. (1977) "An automatic method for deriving steady-state rate equations" Biochem. J. 165, 55-59.
3. Segel, I. H. (1975) Enzyme Kinetics, John Wiley, New York.