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| Bibliography |
| Selected publications by Petr Kuzmic, Ph.D., proprietor of BioKin Ltd. |
Petr Kuzmic - Selected Bibliography
"Mixed-type noncompetitive inhibition of anthrax Lethal Factor protease by aminoglycosides"
Kuzmic, P.; Lynne Cregar, L.; Millis S. Z.; and Goldman, M. (2006) FEBS J. 273, 3054–3062
[ Full Text PDF ]
"A generalized numerical approach to rapid-equilibrium enzyme kinetics: Application to 17beta-HSD"
Kuzmic, P. (2006) Mol. Cell. Endocrinol. 248, 172–181
[ Full Text PDF ]
"Molecular Characterization of Ancylostoma ceylanicum Kunitz-Type Serine Protease Inhibitor: Evidence for a Role in Hookworm-Associated Growth Delay"
Chu, D.; Bungiro, Jr., R. D.; Ibanez, M.; Harrison, L. M.; Campodonico, E.;
Jones, B. F.; Mieszczanek, J.; Kuzmic, P. and Cappello, M. (2004) Infect. Immun. 72, 2214-2221
[ Full Text PDF ]
"Practical Robust Fit of Enzyme Inhibition Data"
Kuzmic, P.; Hill, C.; Janc, J.W. (2004) Meth. Enzymol. 383, 366-381
[ Full text ]
[ Full Text PDF ]
"Kinetic determination of tight binding impurities in enzyme inhibitors"
Kuzmic, P.; Hill, C.; Kirtley, M. P.; Janc, J.W. (2003) Anal. Biochem., 319 272–279
[ Full text ]
[ Full Text PDF ]
"Effect of ribavirin and amantadine on early hepatitis C virus RNA rebound and clearance in serum during daily high-dose interferon"
Lake-Bakaar, G.; Ruffini, L.; Kuzmic, P. (2003) Dig. Dis. Sci. 48, 126-139
[ Full Text PDF ]
"A detailed physical map of the 6p reading disability locus, including new markers and confirmation of recombination suppression"
Ahn, J.; Won, T.W.; Kaplan, D.E.; Londin, E.R.; Kuzmic, P.; Gelernter, J.; Gruen, J.R. (2002) Hum. Genet. 111, 339-349
[ Full Text PDF ]
"Molecular characterization of Ancylostoma inhibitors of coagulation factor Xa: hookworm anticoagulant activity in vitro predicts parasite bloodfeeding in vivo."
Harrison, L.M.; Nerlinger, A.; Bungiro, R.D.; Córdova, J.L.; Kuzmic, P.; and Cappello, M. (2002) J. Biol. Chem. 277, 6223-9.
[ Abstract ]
[ Full Text PDF ]
"The effect of combining interferon, ribavirin and amantadine an
hepatitis C viral dynamics: Further evidence that ribavirin and amantadine block de novo re-infection"
Lake-Bakaar, G.; Ruffini, L.; Kuzmic, P. (2001) Gastroenterology 120, 151.
"A broad spectrum Kunitz-type serine protease inhibitor secreted by the hookworm, Ancylostoma ceylanicum"
Milstone, A.M.; Harrison, L.M.; Bungiro, R.D.; Kuzmic, P.; and Cappello, M. (2000) J. Biol. Chem. 275, 29391-9.
[ Abstract ]
[ Full Text PDF ]
"High-throughput enzyme kinetics: Simultaneous determination of tight-binding inhibition constants and enzyme concentration"
Kuzmic, P.; Elrod, K.C.; Cregar, L.M.; Sideris, S; Rai, R.; and Janc, J.W. (2000) Anal. Biochem. 286, 45-50.
[ Abstract ]
[ Full Text PDF ]
"Dynamics of HLA-1 beta-2-Microglobulin subunit during treatment with high dose Interferon with or without Ribavirin: correlation with serum HCV RNA and ALT"
Lake-Bakaar, G.; Ruffini, L.; and Kuzmic, P. (2000) Digest. Dis. Week , San Diego, May 22-25, 2000.
"Dynamics of HLA-1 beta-2-Microglobulin subunit during treatment with high dose Interferon with or without Ribavirin: correlation with serum HCV RNA and ALT"
Lake-Bakaar, G.; Ruffini, L.; and Kuzmic, P. (2000) Digest. Dis. Week , San Diego, May 22-25, 2000.
"Early HCV RNA 'rebound' during daily high dose Interferon treatment: Inhibition by Ribavirin of possible resistant quasispecies"
Lake-Bakaar, G.; Ruffini, L.; and Kuzmic, P. (2000) Digest. Dis. Week , San Diego, May 22-25, 2000.
"High-throughput screening of enzyme inhibitors: Automatic determination of tight-binding inhibition constants"
Kuzmic, P.; Sideris, S; Cregar, L.M.; Elrod, K.C.; Rice, K.D.; and Janc, J.W. (2000) Anal. Biochem. 281, 62-67.
[ Abstract ]
[ Full Text PDF ]
"General numerical treatment of competitive binding kinetics: Application to thrombin-dehydrothrombin-hirudin"
Kuzmic, P. (1999) Anal. Biochem. 267, 17-23.
[ Abstract ]
[ Full Text PDF ]
[ MedLine ]
"Fixed-point methods for computing the equilibrium composition of complex biochemical mixtures."
Kuzmic, P. (1998) Biochem. J. 331 (Pt 2), 571-5.
[ Abstract ]
[ MedLine ]
"Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase."
Kuzmic, P. (1996) Anal. Biochem. 237, 260-73.
[ Abstract ]
[ Full Text PDF ]
[ MedLine ]
"Mechanical effects on the kinetics of the HIV proteinase deactivation."
Kuzmic, P.; Peranteau, A.G.; Garcia-Echeverria, G.; and Rich, D.H. (1996) Biochem. Biophys. Res. Commun. 221, 313-7.
[ Abstract ]
[ MedLine ]
"Inhibition of human steroid 5alpha reductases type I and II by 6-aza- steroids: structural determinants of one-step vs two-step mechanism."
Moss, M.L.; Kuzmic, P.; Stuart, J.D.; Tian, G.; Peranteau, A.G.; Frye, S.V.; Kadwell, S.H.; Kost, T.A.; Overton, L.K.; and Patel, I.R. (1996) Biochemistry 35, 3457-64.
[ Abstract ]
[ MedLine ]
"Increase in fluorescence upon the hydrolysis of tyrosine peptides: application to proteinase assays."
Peranteau, A.G.; Kuzmic, P.; Angell, Y.; Garcia-Echeverria, C.; and Rich, D.H. (1995) Anal. Biochem. 227, 242-5.
[ Abstract ]
[ MedLine ]
"Stabilization of HIV proteinase dimer by bound substrate."
Kuzmic, P.; Garcia-Echeverria, C.; and Rich, D.H. (1993) Biochem. Biophys. Res. Commun. 194, 301-5.
[ Abstract ]
[ MedLine ]
"Kinetic assay for HIV proteinase subunit dissociation."
Kuzmic, P. (1993) Biochem. Biophys. Res. Commun. 191, 998-1003.
[ Abstract ]
[ MedLine ]
"A continuous spectrophotometric direct assay for peptidyl prolyl cis- trans isomerases."
Garcia-Echeverria, C.; Kofron, J.L.; Kuzmic, P.; and Rich, D.H. (1993) Biochem. Biophys. Res. Commun. 191, 70-5.
[ Abstract ]
[ MedLine ]
"Radical reduction of C-Cl bonds in chlorofluoroethers"
Liska, F.; Fikar, J.; and Kuzmic, P. (1993) Collect. Czech. Chem. Commun. 58, 565-573.
"Identification of actin and HSP 70 as cyclosporin A binding proteins by photoaffinity labeling and fluorescence displacement assays."
Moss, M.L.; Palmer, R.E.; Kuzmic, P.; Dunlap, B.E.; Henzel, W.; Kofron, J.L.; Mellon, W.S.; Royer, C.A.; and Rich, D.H. (1992) J. Biol. Chem. 267, 22054-9.
[ Abstract ]
[ MedLine ]
"Fluorescence displacement method for the determination of receptor- ligand binding constants."
Kuzmic, P.; Moss, M.L.; Kofron, J.L.; and Rich, D.H. (1992) Anal. Biochem. 205, 65-9.
[ Abstract ]
[ MedLine ]
"Mixtures of tight-binding enzyme inhibitors. Kinetic analysis by a recursive rate equation."
Kuzmic, P.; Ng, K.Y.; and Heath, T.D. (1992) Anal. Biochem. 200, 68-73.
[ Abstract ]
[ MedLine ]
"Mathematical models for the kinetics of peptidyl-prolyl cis-trans isomerases"
Kuzmic, P.; Kofron, J.L.; Kishore, V. and Rich, D.H. (1992) Peptides - Chemistry and Biology , 470-1.
"Continuous fluorimetric direct (uncoupled) assay for peptidyl-prolyl cis - trans isomerases"
Garcia-Echeverria, C.; Kofron, J.L.; Kuzmic, P.; Kishore, V. and Rich, D.H. (1992) J. Amer. Chem. Soc. 114, 2758-9.
"Lithium chloride perturbation of cis-trans peptide bond equilibria: effect on conformational equilibria in cyclosporin A and time-dependent inhibition of cyclophilin"
Kofron, J.L.; Kuzmic, P.; Kishore, V., Gemmecker, G.; Fesik, S.W. and Rich, D.H. (1992) J. Amer. Chem. Soc. 114, 2670-5.
"Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay [published erratum appears in Biochemistry 1991 Nov 5;30(44):10818]"
Kofron, J.L.; Kuzmic, P.; Kishore, V.; Colon-Bonilla, E.; and Rich, D.H. (1991) Biochemistry 30, 6127-34.
[ Abstract ]
[ MedLine ]
"Nonspecific electrostatic binding of substrates and inhibitors to porcine pepsin"
Kuzmic, P.; Sun, C.Q.; Zhao, Z.C.; and Rich, D.H. (1991) Adv. Exper. Med. Biol. 306, 75-86.
[ MedLine ]
"Long range electrostatic effects in pepsin catalysis"
Kuzmic, P.; Sun, C.Q.; Zhao, Z.C.; and Rich, D.H. (1991) Tetrahedron 47, 2519-34.
"Benzophenone analogs of pepstatin A and cyclosporin A as potential photoaffinity labeling reagents"
P. Kuzmic, C.-Q. Sun and D. H. Rich (1991) Peptides - Chemistry, Structure and Biology , 129-31.
"Purification of 2-chloro-1,1,2-trifluoroethyl dichloromethyl ether as an inhalation anesthetic intermediate"
Dedek, V.; Liska, F.; Fikar, J.; Kuzmic, P.; Pavlovska, E.; Salamon, M.; and Simon, J. (1988) Czech. Pat. (Chem. Abstr. 166972) CS , 237734.
"Preparation of 2-chloro-1,1,2-trifluoroethyl dichloromethyl ether as an inhalation anesthetic intermediate"
Dedek, V.; Liska, F.; Kuzmic, P.; Fikar, J.; Vesely, M.; Pavlovska, E.; and Simon, J. (1988) Czech. Pat. (Chem. Abstr. 166971) CS , 237733.
"Substituent effects in aromatic photochemistry. UV irradiation of 3,4-dimethoxybenzonitrile and 3,4-dimethoxyacetophenone in the presence of inorganic anions"
Kuzmic, P. and Soucek, M. (1987) Collect. Czech. Chem. Commun. 52, 980-8.
"Photoreaction of N-butyl 3,4-dimethoxy-6-nitrobenzamide with butylamine. A model study for lysine-directed photoaffinity labeling"
Kuzmic, P.; Pavlickova, L. and Soucek, M. (1987) Collect. Czech. Chem. Commun. 52, 1780-5.
"Regioselectivity of nuclephilic aromatic photosubstitution in the biphenyl series. Photohydrolysis of some dimethoxynitrobiphenyls"
Urban, J.; Kuzmic, P.; Saman, D.; and Soucek, M. (1987) Collect. Czech. Chem. Commun. 52, 2482-91.
"Photo-cyanation of 3,4-di-methoxy-1-nitro-benzene. A quantitative study"
Kuzmic, P. and Soucek, M. (1986) Collect. Czech. Chem. Commun. 51, 358-67.
"Chemical actinometry in the UV range based on the photohydrolysis of 3,4-dimethoxy-1-nitro benzene"
Pavlickova, L., Kuzmic, P.; and Soucek, M. (1986) Collect. Czech. Chem. Commun. 51, 368-74.
"Photoreaction of 3,4-dimethoxy-1-nitrobenzene with butylamine. A pH dependence of regioselectivity"
Kuzmic, P.; Pavlickova, L.; Velek, J. and Soucek, M. (1986) Collect. Czech. Chem. Commun. 51, 1665-70.
"Photochemical hydrolysis of some nitrophenyl acetates"
Kuzmic, P.; Pavlickova, L. and Soucek, M. (1986) Collect. Czech. Chem. Commun. 51, 1293-300.
"Free-radical induced reduction of C-Cl bonds in chlorofluoroethers by alcohols and ethers"
Dedek, V.; Liska, F.; Fikar, J.; and Kuzmic, P. (1985) J. Fluorine Chem. 29, 152.
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