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Citation Analysis
References to selected publications

Bibliographic citations to research articles published by Dr. Petr Kuzmic, proprietor of BioKin Ltd (last updated January 29, 2006).

Citation statistics

Research articles and book chapters published by Dr. Petr Kuzmic have been cited 836 times (1/29/2006) in other journal articles and books. In 2004 and 2005, the number of annual citations exceeded one hundred. The most highly cited paper (307 citations) has been the original article describing the program DYNAFIT - see section #17 below.

P.Kuzmic citations

P.Kuzmic citations

Complete list of citations


1Top of pageNext section
"Molecular characterization of Ancylostoma ceylanicum Kunitz-type serine protease inhibitor: Evidence for a role in hookworm-associated growth delay"
Chu, D; Bungiro, RD; Ibanez, M; Harrison, LM; Campodonico, E; Jones, BF; Mieszczanek, J; Kuzmic, P; Cappello, M (2004)
Infect. Immun. 72(4), 2214-2221.
Citations
  1. "Hookworm infection: new developments and prospects for control"
    Bungiro, R; Cappello, M (2004)
    Curr. Opin. Infect. Dis. 17(5), 421-426.

  2. "Ancylostoma ceylanicum anticoagulant peptide-1: role of the predicted reactive site amino acid in mediating inhibition of coagulation factors Xa and VIIa"
    Mieszczanek, J; Harrison, LM; Cappello, M (2004)
    Mol. Biochem. Parasitol. 137(1), 151-159.

  3. "Purification and molecular cloning of and immunization with Ancylostoma ceylanicum excretory-secretory protein 2, an immunoreactive protein produced by adult hookworms"
    Bungiro, RD; Solis, CV; Harrison, LA; Cappello, M (2004)
    Infect. Immun. 72(4), 2203-2213.

  4. "Characterization of a novel filarial serine protease inhibitor, Ov-SPI-1, from Onchocerca volvulus, with potential multifunctional roles during development of the parasite"
    Ford, L; Guiliano, DB; Oksov, Y; Debnath, AK; Liu, J; Williams, SA; Blaxter, ML; Lustigman, S (2005)
    J. Biol. Chem. 280(49), 40845-40856.

  5. "Detection of excretory/secretory coproantigens in experimental hookworm infection"
    Bungiro, RD; Cappello, M (2005)
    Am. J. Trop. Med. Hyg. 73(5), 915-920.

  6. "Host cytokine production, lymphoproliferation, and antibody responses during the course of Ancylostoma ceylanicum infection in the Golden Syrian hamster"
    Mendez, S; Valenzuela, JG; Wu, WH; Hotez, PJ (2005)
    Infect. Immun. 73(6), 3402-3407.


2Top of pageNext section
"Mechanism of loading the Escherichia coli DNA polymerase III sliding clamp - I. Two distinct activities for individual ATP sites in the gamma complex"
Williams, CR; Snyder, AK; Kuzmic, P; O'Donnell, M; Bloom, LB (2004)
J. Biol. Chem. 279(6), 4376-4385.
Citations
  1. "On the solution structure of the T4 sliding clamp (gp45)"
    Millar, D; Trakselis, MA; Benkovic, SJ (2004)
    Biochemistry 43(40), 12723-12727.

  2. "Dual functions, clamp opening and primer-template recognition, define a key clamp loader subunit"
    Coman, MM; Jin, M; Ceapa, R; Finkelstein, J; O'Donnell, M; Chait, BT; Hingorani, MM (2004)
    J. Mol. Biol. 342(5), 1457-1469.

  3. "'Screw-cap' clamp loader proteins that thread"
    Zhuang, Z; Spiering, MM; Berdis, AJ; Trakselis, MA; Benkovic, SJ (2004)
    Nat. Struct. Mol. Biol. 11(7), 580-581.

  4. "Mechanism of loading the Escherichia coli DNA polymerase III sliding clamp - II. Uncoupling the beta and DNA binding activities of the gamma complex"
    Snyder, AK; Williams, CR; Johnson, A; O'Donnell, M; Bloom, LB (2004)
    J. Biol. Chem. 279(6), 4386-4393.

  5. "The opened processivity clamp slides into view"
    Jeruzalmi, D (2005)
    Proc. Natl. Acad. Sci. U. S. A. 102(42), 14939-14940.

  6. "Cellular DNA replicases: Components and dynamics at the replication fork"
    Johnson, A; O'Donnell, M (2005)
    Annu. Rev. Biochem. 74, 283-315.

  7. "The bacteriophage P1 hot gene product can substitute for the Escherichia coli DNA polymerase III theta subunit"
    Chikova, AK; Schaaper, RM (2005)
    J. Bacteriol. 187(16), 5528-5536.

  8. "Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex"
    Kazmirski, SL; Podobnik, M; Weitze, TF; O'Donnelll, M; Kuriyan, J (2004)
    Proc. Natl. Acad. Sci. U. S. A. 101(48), 16750-16755.


3Top of pageNext section
"Practical Robust Fit of Enzyme Inhibition Data"
Kuzmic, P; Hill, C; Janc, J (2004)
Methods Enzymol. 383, 366-381.
Citations
  1. "Structural basis for the highly selective inhibition of MMP-13"
    Engel, CK; Pirard, B; Schimanski, S; Kirsch, R; Habermann, J; Klingler, O; Schlotte, V; Weithmann, KU; Wendt, KU (2005)
    Chem. Biol. 12(2), 181-189.

  2. "A novel HIV-1 antiviral high throughput screening approach for the discovery of HIV-1 inhibitors"
    Blair, WS; Isaacson, J; Li, XQ; Cao, J; Peng, QH; Kong, GFZ; Patick, AK (2005)
    Antiviral Res. 65(2), 107-116.


4Top of pageNext section
"Effect of ribavirin and amantadine on early hepatitis C virus RNA rebound and clearance in serum during daily high-dose interferon"
Lake-Bakaar, G; Ruffini, L; Kuzmic, P (2003)
Dig. Dis. Sci. 48(1), 126-139.
Citations
  1. "Viral kinetics and hepatitis C"
    Lake-Bakaar, G; Frost, SDW (2003)
    Hepatology 38(6), 1588-1588.

  2. "Viral kinetics and hepatitis C - Reply"
    Perelson, AS; Ribeiro, RM; Layden-Almer, JE; Layden, TJ (2003)
    Hepatology 38(6), 1588-1589.

  3. "Evaluation of amantadine in chronic hepatitis C: a meta-analysis"
    Deltenre, P; Henrion, J; Canva, V; Dharancy, S; Texier, F; Louvet, A; De Maeght, S; Paris, JC; Mathurin, P (2004)
    J. Hepatol. 41(3), 462-473.

  4. "Hepatitis C-virus - Virus kinetics and resistance mechanisms"
    Herrmann, E; Sarrazin, C (2004)
    Z. Gastroent. 42(5), 387-396.

  5. "A randomized controlled trial of pegylated interferon alpha-2a (40 KD) or interferon alpha-2a plus ribavirin and amantadine vs interferon alpha-2a and ribavirin in treatment-naive patients with chronic hepatitis C"
    Mangia, A; Ricci, GL; Persico, M; Minerva, N; Carretta, V; Bacca, D; Cela, M; Piattelli, M; Annese, M; Maio, G; Conte, D; Guadagnino, V; Pazienza, V; Festi, D; Spirito, F; Andriulli, A (2005)
    J. Viral Hepatitis 12(3), 292-299.


5Top of pageNext section
"Kinetic determination of tight-binding impurities in enzyme inhibitors"
Kuzmic, P; Hill, C; Kirtley, MP; Janc, JW (2003)
Anal. Biochem. 319(2), 272-279.
Citations
  1. "Influence of DNA structure on DNA polymerase beta active site function - Extension of mutagenic DNA intermediates"
    Beard, WA; Shock, DD; Wilson, SH (2004)
    J. Biol. Chem. 279(30), 31921-31929.

  2. "Practical robust fit of enzyme inhibition data"
    Kuzmic, P; Hill, C; Janc, JW (2004)
    Methods Enzymol. 383, 366-381.


6Top of pageNext section
"A detailed physical map of the 6p reading disability locus, including new markers and confirmation of recombination suppression"
Ahn, J; Won, TW; Kaplan, DE; Londin, ER; Kuzmic, P; Gelernter, J; Gruen, JR (2002)
Hum. Genet. 111(4-5), 339-349.
Citations
  1. "A transcription map of the 6p22.3 reading disability locus identifying candidate genes"
    Londin, ER; Meng, HY; Gruen, JR (2003)
    BMC Genomics 4, .

  2. "Mutually exclusive recombination of wild-type and mutant loxP sites in vivo facilitates transposon-mediated deletions from both ends of genomic DNA in PACs"
    Chatterjee, PK; Shakes, LA; Srivastava, DK; Garland, DM; Harewood, KR; Moore, KJ; Coren, JS (2004)
    Nucleic Acids Res. 32(18), 5668-5676.


7Top of pageNext section
"Molecular characterization of Ancylostoma inhibitors of coagulation factor Xa - Hookworm anticoagulant activity in vitro predicts parasite bloodfeeding in vivo"
Harrison, LM; Nerlinger, A; Bungiro, RD; Cordova, JL; Kuzmic, P; Cappello, M (2002)
J. Biol. Chem. 277(8), 6223-6229.
Citations
  1. "A novel family of anticoagulants from the saliva of Ixodes scapularis"
    Narasimhan, S; Koski, RA; Beaulieu, B; Anderson, JF; Ramamoorthi, N; Kantor, F; Cappello, M; Fikrig, E (2002)
    Insect Mol. Biol. 11(6), 641-650.

  2. "Some aspects of parasitology and immunology in general medicine"
    Frydas, S; Madhappan, B; Kempuraj, D (2002)
    Int. J. Immunopathol. Pharmacol. 15(3), 165-170.

  3. "Inhibition mechanisms of hematophagous invertebrate compounds acting on the host blood coagulation and platelet aggregation pathways"
    Urata, J; Shojo, H; Kaneko, Y (2003)
    Biochimie 85(5), 493-500.

  4. "Ancylostoma ceylanicum anticoagulant peptide-1: role of the predicted reactive site amino acid in mediating inhibition of coagulation factors Xa and VIIa"
    Mieszczanek, J; Harrison, LM; Cappello, M (2004)
    Mol. Biochem. Parasitol. 137(1), 151-159.

  5. "Helminths at mucosal barriers - interaction with the immune system"
    Mulcahy, G; O'Neill, S; Donnelly, S; Dalton, JP (2004)
    Adv. Drug Deliv. Rev. 56(6), 853-868.

  6. "Molecular characterization of Ancylostoma ceylanicum Kunitz-type serine protease inhibitor: Evidence for a role in hookworm-associated growth delay"
    Chu, D; Bungiro, RD; Ibanez, M; Harrison, LM; Campodonico, E; Jones, BF; Mieszczanek, J; Kuzmic, P; Cappello, M (2004)
    Infect. Immun. 72(4), 2214-2221.

  7. "Disruption of Ixodes scapularis anticoagulation by using RNA interference"
    Narasimhan, S; Montgomery, RR; DePonte, K; Tschudi, C; Marcantonio, N; Anderson, JF; Sauer, JR; Cappello, M; Kantor, FS; Fikrig, E (2004)
    Proc. Natl. Acad. Sci. U. S. A. 101(5), 1141-1146.

  8. "Anticoagulant peptides from Ancylostoma caninum are immunologically distinct and localize to separate structures within the adult hookworm"
    Mieszczanek, J; Harrison, LM; Vlasuk, GP; Cappello, M (2004)
    Mol. Biochem. Parasitol. 133(2), 319-323.

  9. "Characterization of a novel filarial serine protease inhibitor, Ov-SPI-1, from Onchocerca volvulus, with potential multifunctional roles during development of the parasite"
    Ford, L; Guiliano, DB; Oksov, Y; Debnath, AK; Liu, J; Williams, SA; Blaxter, ML; Lustigman, S (2005)
    J. Biol. Chem. 280(49), 40845-40856.

  10. "Detection of excretory/secretory coproantigens in experimental hookworm infection"
    Bungiro, RD; Cappello, M (2005)
    Am. J. Trop. Med. Hyg. 73(5), 915-920.

  11. "Bioactive compounds in tick and mite venoms (saliva)"
    Tu, AT; Motoyashiki, T; Azimov, DA (2005)
    Toxin Rev. 24(2), 143-174.

  12. "Human hookworm infection in the 21st century"
    Brooker, S; Bethony, J; Hotez, PJ (2004)
    Adv.Parasitol. 58, 197-288.


8Top of pageNext section
"The effect of combining interferon, ribavirin and amantadine an hepatitis C viral dynamics: Further evidence that ribavirin and amantadine block de novo re-infection."
Lake-Bakaar, G; Ruffini, L; Kuzmic, P (2001)
Gastroenterology 120(5), A29-A29.
Citations


9Top of pageNext section
"A broad spectrum Kunitz type serine protease inhibitor secreted by the hookworm Ancylostoma ceylanicum"
Milstone, AM; Harrison, LM; Bungiro, RD; Kuzmic, P; Cappello, M (2000)
J. Biol. Chem. 275(38), 29391-29399.
Citations
  1. "Amino acid sequence of a trypsin inhibitor from a Spirometra (Spirometra erinaceieuropaei)"
    Sanda, A; Uchida, A; Itagaki, T; Kobayashi, H; Inokuchi, N; Koyama, T; Iwama, M; Ohgi, K; Irie, M (2001)
    Biol. Pharmacol. Bull. 24(12), 1356-1361.

  2. "Immune responses in hookworm infections"
    Loukas, A; Prociv, P (2001)
    Clin. Microbiol. Rev. 14(4), 689-703.

  3. "Ancylostoma caninum anticoagulant peptide-5: immunolocalization and in vitro neutralization of a major hookworm anti-thrombotic"
    Harrison, LM; Cordova, JL; Cappello, M (2001)
    Mol. Biochem. Parasitol. 115(1), 101-107.

  4. "Mitigation of hookworm disease by immunization with soluble extracts of Ancylostoma ceylanicum"
    Bungiro, RD; Greene, J; Kruglov, E; Cappello, M (2001)
    J. Infect. Dis. 183(9), 1380-1387.

  5. "Functional analysis of Toxoplasma gondii protease inhibitor 1"
    Morris, MT; Coppin, A; Tomavo, S; Carruthers, VB (2002)
    J. Biol. Chem. 277(47), 45259-45266.

  6. "Exploring the sialome of the tick Ixodes scapularis"
    Valenzuela, JG; Francischetti, IMB; Pham, VM; Garfield, MK; Mather, TN; Ribeiro, JMC (2002)
    J. Exp. Biol. 205(18), 2843-2864.

  7. "Molecular characterization of Ancylostoma inhibitors of coagulation factor Xa - Hookworm anticoagulant activity in vitro predicts parasite bloodfeeding in vivo"
    Harrison, LM; Nerlinger, A; Bungiro, RD; Cordova, JL; Kuzmic, P; Cappello, M (2002)
    J. Biol. Chem. 277(8), 6223-6229.

  8. "Ancylostoma ceylanicum excretory/secretory protein 1: purification and molecular cloning of a major secretory protein from adult hookworms"
    Bungiro, RD; Harrison, LM; Cappello, M (2002)
    Mol. Biochem. Parasitol. 119(1), 147-151.

  9. "Uncinaria stenocephala: antigenic characterization of larvae and adults worms using sera from naturally infected dogs"
    Postigo, I; Martinez, J; Cardona, G; Fernandez-Perez, I; Guisantes, JA (2003)
    Exp. Parasitol. 103(3-4), 171-173.

  10. "Isolation and molecular cloning of a secreted hookworm platelet inhibitor from adult Ancylostoma caninum"
    Del Valle, A; Jones, BF; Harrison, LM; Chadderdon, RC; Cappello, M (2003)
    Mol. Biochem. Parasitol. 129(2), 167-177.

  11. "Molecular cloning of a novel multidomain Kunitz-type proteinase inhibitor from the hookworm Ancylostoma caninum"
    Hawdon, JM; Datu, B; Crowell, M (2003)
    J. Parasitol. 89(2), 402-407.

  12. "Oral transfer of adult Ancylostoma ceylanicum hookworms into permissive and nonpermissive host species"
    Bungiro, RD; Anderson, BR; Cappello, M (2003)
    Infect. Immun. 71(4), 1880-1886.

  13. "Characterisation of humoral immune responses in dogs vaccinated with irradiated Ancylostoma caninum"
    Boag, PR; Parsons, JC; Presidente, PJA; Spithill, TW; Sexton, JL (2003)
    Vet. Immunol. Immunopathol. 92(1-2), 87-94.

  14. "Hookworm infection: new developments and prospects for control"
    Bungiro, R; Cappello, M (2004)
    Curr. Opin. Infect. Dis. 17(5), 421-426.

  15. "Ancylostoma ceylanicum anticoagulant peptide-1: role of the predicted reactive site amino acid in mediating inhibition of coagulation factors Xa and VIIa"
    Mieszczanek, J; Harrison, LM; Cappello, M (2004)
    Mol. Biochem. Parasitol. 137(1), 151-159.

  16. "A Kazal-like extracellular serine protease inhibitor from Phytophthora infestans targets the tomato pathogenesis-related protease P69B"
    Tian, MY; Huitema, E; da Cunha, L; Torto-Alalibo, T; Kamoun, S (2004)
    J. Biol. Chem. 279(25), 26370-26377.

  17. "Purification and molecular cloning of and immunization with Ancylostoma ceylanicum excretory-secretory protein 2, an immunoreactive protein produced by adult hookworms"
    Bungiro, RD; Solis, CV; Harrison, LA; Cappello, M (2004)
    Infect. Immun. 72(4), 2203-2213.

  18. "Molecular characterization of Ancylostoma ceylanicum Kunitz-type serine protease inhibitor: Evidence for a role in hookworm-associated growth delay"
    Chu, D; Bungiro, RD; Ibanez, M; Harrison, LM; Campodonico, E; Jones, BF; Mieszczanek, J; Kuzmic, P; Cappello, M (2004)
    Infect. Immun. 72(4), 2214-2221.

  19. "Detection of excretory/secretory coproantigens in experimental hookworm infection"
    Bungiro, RD; Cappello, M (2005)
    Am. J. Trop. Med. Hyg. 73(5), 915-920.

  20. "Have gastrointestinal nematodes outwitted the immune system?"
    Else, KJ (2005)
    Parasite Immunol. 27(10-11), 407-415.

  21. "Expressed sequence tags from the oomycete fish pathogen Saprolegnia parasitica reveal putative virulence factors"
    Torto-Alalibo, T; Tian, MY; Gajendran, K; Waugh, ME; van West, P; Kamoun, S (2005)
    BMC Microbiol. 5, .

  22. "Human hookworm infection in the 21st century"
    Brooker, S; Bethony, J; Hotez, PJ (2004)
    Adv.Parasitol. 58, 197-288.


10Top of pageNext section
"High-throughput screening of enzyme inhibitors: Automatic determination of light-binding inhibition constants"
Kuzmic, P; Sideris, S; Cregar, LM; Elrod, KC; Rice, KD; Janc, JW (2000)
Anal. Biochem. 281(1), 62-67.
Citations
  1. "A broad spectrum Kunitz type serine protease inhibitor secreted by the hookworm Ancylostoma ceylanicum"
    Milstone, AM; Harrison, LM; Bungiro, RD; Kuzmic, P; Cappello, M (2000)
    J. Biol. Chem. 275(38), 29391-29399.

  2. "Exploiting subsite S1 of trypsin-like serine proteases for selectivity: Potent and selective inhibitors of urokinase-type plasminogen activator"
    Mackman, RL; Katz, BA; Breitenbucher, JG; Hui, HC; Verner, E; Luong, C; Liu, L; Sprengeler, PA (2001)
    J. Med. Chem. 44(23), 3856-3871.

  3. "Development of serine protease inhibitors displaying a multicentered short (< 2.3 angstrom) hydrogen bond binding mode: Inhibitors of urokinase-type plasminogen activator and factor Xa"
    Verner, E; Katz, BA; Spencer, JR; Allen, D; Hataye, J; Hruzewicz, W; Hui, HC; Kolesnikov, A; Li, Y; Luong, C; Martelli, A; Radika, K; Rai, R; She, M; Shrader, W; Sprengeler, PA; Trapp, S; Wang, J; Young, WB; Mackman, RL (2001)
    J. Med. Chem. 44(17), 2753-2771.

  4. "Neutral inhibitors of the serine protease factor Xa"
    Shrader, WD; Young, WB; Sprengeler, PA; Sangalang, JC; Elrod, K; Carr, G (2001)
    Bioorg. Med. Chem. Lett. 11(14), 1801-1804.

  5. "Mechanistic implications of methylglyoxal synthase complexed with phosphoglycolohydroxamic acid as observed by X-ray crystallography and NMR spectroscopy"
    Marks, GT; Harris, TK; Massiah, MA; Mildvan, AS; Harrison, DHT (2001)
    Biochemistry 40(23), 6805-6818.

  6. "A novel serine protease inhibition motif involving a multi- centered short hydrogen bonding network at the active site"
    Katz, BA; Elrod, K; Luong, C; Rice, MJ; Mackman, RL; Sprengeler, PA; Spencer, J; Hataye, J; Janc, J; Link, J; Litvak, J; Rai, R; Rice, K; Sideris, S; Verner, E; Young, W (2001)
    J. Mol. Biol. 307(5), 1451-1486.

  7. "Highly potent non-peptidic inhibitors of the HCVNS3/NS4A serine protease"
    Sperandio, D; Gangloff, AR; Litvak, J; Goldsmith, R; Hataye, JM; Wang, VR; Shelton, EJ; Elrod, K; Janc, JW; Clark, JM; Rice, K; Weinheimer, S; Yeung, KS; Meanwell, NA; Hernandez, D; Staab, AJ; Venables, BL; Spencer, JR (2002)
    Bioorg. Med. Chem. Lett. 12(21), 3129-3133.

  8. "Novel route to the synthesis of peptides containing 2-amino-1 '-hydroxymethyl ketones and their application as cathepsin K inhibitors"
    Mendonca, RV; Venkatraman, S; Palmer, JT (2002)
    Bioorg. Med. Chem. Lett. 12(20), 2887-2891.

  9. "Contribution of multicentered short hydrogen bond arrays to potency of active site-directed serine protease inhibitors"
    Katz, BA; Spencer, JR; Elrod, K; Luong, C; Mackman, RL; Rice, M; Sprengeler, PA; Allen, D; Janc, J (2002)
    J. Am. Chem. Soc. 124(39), 11657-11668.

  10. "Peptidic 1-cyanopyrrolidines: Synthesis and SAR of a series of potent, selective cathepsin inhibitors"
    Rydzewski, RM; Bryant, C; Oballa, R; Wesolowski, G; Rodan, SB; Bass, KE; Wong, DH (2002)
    Bioorg. Med. Chem. 10(10), 3277-3284.

  11. "Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets"
    Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL (2001)
    Chem. Biol. 8(11), 1107-1121.

  12. "Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor"
    Selwood, T; Elrod, KC; Schechter, NM (2003)
    Biol. Chem. 384(12), 1605-1611.

  13. "Novel class of bivalent glutathione S-transferase inhibitors"
    Lyon, RP; Hill, JJ; Atkins, WM (2003)
    Biochemistry 42(35), 10418-10428.

  14. "Kinetic determination of tight-binding impurities in enzyme inhibitors"
    Kuzmic, P; Hill, C; Kirtley, MP; Janc, JW (2003)
    Anal. Biochem. 319(2), 272-279.

  15. "Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors"
    Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VWF; Hui, HC; Breitenbucher, G; Allen, D; Janc, JW (2003)
    J. Mol. Biol. 329(1), 93-120.

  16. "Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA)"
    Katz, BA; Luong, C; Ho, JD; Somoza, JR; Gjerstad, E; Tang, J; Williams, SR; Verner, E; Mackman, RL; Young, WB; Sprengeler, PA; Chan, H; Mortara, K; Janc, JW; McGrath, ME (2004)
    J. Mol. Biol. 344(2), 527-547.

  17. "Biochemical characterization of prostasin, a channel activating protease"
    Shipway, A; Danahay, H; Williams, JA; Tully, DC; Backes, BJ; Harris, JL (2004)
    Biochem. Biophys. Res. Commun. 324(2), 953-963.

  18. "Enzyme microarrays: On-chip determination of inhibition constants based on affinity-label defection of enzymatic activity"
    Eppinger, J; Funeriu, DP; Miyake, M; Denizot, L; Miyake, J (2004)
    Angew. Chem.-Int. Edit. 43(29), 3806-3810.

  19. "Practical robust fit of enzyme inhibition data"
    Kuzmic, P; Hill, C; Janc, JW (2004)
    Methods Enzymol. 383, 366-381.

  20. "Determination of accurate K-I values for tight-binding enzyme inhibitors: an in silico study of experimental error and assay design"
    Murphy, DJ (2004)
    Anal. Biochem. 327(1), 61-67.

  21. "A new member of the bacterial ribonuclease inhibitor family from Saccharopolyspora erythraea"
    Krajcikova, D; Hartley, RW (2004)
    FEBS Lett. 557(1-3), 164-168.

  22. "Peptide ketobenzoxazole inhibitors bound to cathepsin K"
    McGrath, ME; Sprengeler, PA; Hill, CM; Martichonok, V; Cheung, H; Somoza, JR; Palmer, JT; Janc, JW (2003)
    Biochemistry 42(51), 15018-15028.

  23. "Design and synthesis of tri-ring P-3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K"
    Palmer, JT; Bryant, C; Wang, DX; Davis, DE; Setti, EL; Rydzewski, RM; Venkatraman, S; Tian, ZQ; Burrill, LC; Mendonca, RV; Springman, E; McCarter, J; Chung, T; Cheung, H; Janc, JW; McGrath, M; Somoza, JR; Enriquez, P; Yu, ZW; Strickley, RM; Liu, L; Venuti, MC; Percival, MD; Falgueyret, JP; Prasit, P; Oballa, R; Riendeau, D; Young, RN; Wesolowski, G; Rodan, SB; Johnson, C; Kimmel, DB; Rodan, G (2005)
    J. Med. Chem. 48(24), 7520-7534.

  24. "Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein"
    Tang, J; Yu, CL; Williams, SR; Springman, E; Jeffery, D; Sprengeler, PA; Estevez, A; Sampang, J; Shrader, W; Spencer, J; Young, W; McGrath, M; Katz, BA (2005)
    J. Biol. Chem. 280(49), 41077-41089.

  25. "Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries"
    Li, J; Lim, SP; Beer, D; Patel, V; Wen, DY; Tumanut, C; Tully, DC; Williams, JA; Jiricek, J; Priestle, JP; Harris, JL; Vasudevan, SG (2005)
    J. Biol. Chem. 280(31), 28766-28774.

  26. "Enzyme family-specific and activity-based screening of chemical libraries using enzyme microarrays"
    Funeriu, DP; Eppinger, J; Denizot, L; Miyake, M; Miyake, J (2005)
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11Top of pageNext section
"HCV viral dynamics during therapy with high dose interferon-A-2B plus or minus ribavirin: Correlation with ALT suggests ribavirin may suppress early de novo re-infection."
Lake-Bakaar, GV; Ruffini, L; Kuzmic, P (2000)
Gastroenterology 118(Pt. Part 1 Suppl. 2), A1016-A1016.
Citations


12Top of pageNext section
"High-throughput screening of enzyme inhibitors: Simultaneous determination of tight-binding inhibition constants and enzyme concentration"
Kuzmic, P; Elrod, KC; Cregar, LM; Sideris, S; Rai, R; Janc, JW (2000)
Anal. Biochem. 286(1), 45-50.
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    Anal. Biochem. 319(2), 272-279.

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    Biochem. J. 380(Pt. Part 1), 105-110.

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  8. "Purification of cynarases from artichoke (Cynara scolymus L.): enzymatic properties of cynarase A"
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    Phytochemistry 66(1), 41-49.


13Top of pageNext section
"General numerical treatment of competitive binding kinetics: Application to thrombin-dehydrothrombin-hirudin"
Kuzmic, P (1999)
Anal. Biochem. 267(1), 17-23.
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14Top of pageNext section
"Fixed-point methods for computing the equilibrium composition of complex biochemical mixtures"
Kuzmic, P (1998)
Biochem. J. 331(Pt. Part 2), 571-575.
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    Anal. Biochem. 267(1), 17-23.


15Top of pageNext section
"Inhibition of human steroid 5 alpha reductases type I and II by 6-aza-steroids: Structural determinants of one-step vs two-step mechanism"
Moss, ML; Kuzmic, P; Stuart, JD; Tian, GC; Peranteau, AG; Frye, SV; Kadwell, SH; Kost, TA; Overton, LK; Patel, IR (1996)
Biochemistry 35(11), 3457-3464.
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16Top of pageNext section
"Mechanical effects on the kinetics of the HIV proteinase deactivation"
Kuzmic, P; Peranteau, AG; GarciaEcheverria, C; Rich, DH (1996)
Biochem. Biophys. Res. Commun. 221(2), 313-317.
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    Biochemistry 41(4), 1302-1307.


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"Program DYNAFIT for the analysis of enzyme kinetic data: Application to HIV proteinase"
Kuzmic, P (1996)
Anal. Biochem. 237(2), 260-273.
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    Biochemistry 40(31), 9291-9299.

  63. "Characterisation of the structure of ocr, the gene 0.3 protein of bacteriophage T7"
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  64. "A kinetic study of competing fragmentation and hydrolyses of phenyl hydrogen alpha-hydroxyiminobenzylphosphonate - a case of acid mediated inhibition of acid catalysis"
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  65. "Allosteric binding of nucleoside triphosphates to RNA polymerase regulates transcription elongation"
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    Cell 106(2), 243-252.

  66. "The ATPase reaction cycle of yeast DNA topoisomerase II - Slow rates of ATP resynthesis and P-i release"
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  67. "High enzymatic activity and chaperone function are mechanistically related features of the dimeric E-coli peptidyl-prolyl-isomerase FkpA"
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  68. "Reduction of aflatoxin B-1 dialdehyde by rat and human aldo- keto reductases"
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    Chem. Res. Toxicol. 14(6), 727-737.

  69. "The mechanism of DNA cytosine-5 methylation - Kinetic and mutational dissection of HhaI methyltransferase"
    Vilkaitis, G; Merkiene, E; Serva, S; Weinhold, E; Klimasauskas, S (2001)
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  70. "Binding and oxidation of alkyl 4-nitrophenyl ethers by rabbit cytochrome P450 1A2: Evidence for two binding sites"
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    Biochemistry 40(24), 7262-7272.

  71. "Examination of donor substrate conversion in yeast transketolase"
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  72. "Kinetic analysis of three activated phenylalanyl intermediates generated by the initiation module PheATE of gramicidin S synthetase"
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    Biochemistry 40(18), 5329-5337.

  73. "Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase"
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    Appl. Environ. Microbiol. 67(5), 2044-2050.

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    Kaur, K; Pratt, RF (2001)
    Biochemistry 40(15), 4610-4621.

  75. "Spectroscopic properties of the metalloregulatory Cd(II) and Pb(II) sites of S. aureus pI258 CadC"
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    Biochemistry 40(14), 4426-4436.

  76. "Oxidations of p-alkoxyacylanilides catalyzed by human cytochrome P450 1A2: Structure-activity relationships and simulation of rate constants of individual steps in catalysis"
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    Biochemistry 40(14), 4521-4530.

  77. "Acetohydroxyacid synthase: A proposed structure for regulatory subunits supported by evidence from mutagenesis"
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  79. "Thermostable and site-specific DNA binding of the gene product ORF56 from the Sulfolobus islandicus plasmid pRN1, a putative archael plasmid copy control protein"
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    Biochemistry 40(1), 130-142.

  81. "The N-terminal region of cystatin A (stefin A) binds to papain subsequent to the two hairpin loops of the inhibitor. Demonstration of two-step binding by rapid-kinetic studies of cystatin A labeled at the N-terminus with a fluorescent reporter group"
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    Protein Sci. 9(11), 2218-2224.

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    J. Environ. Monit. 2(6), 582-586.

  83. "The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition"
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    Mol. Cell 10(5), 1033-1043.

  84. "Urate oxidase: Single-turnover stopped-flow techniques for detecting two discrete enzyme-bound intermediates"
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    METHODS IN ENZYMOLOGY 354, 310-319.

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    Thromb. Haemost. 88(5), 756-762.

  86. "Kinetic modeling of reactions in heated monosaccharide-casein systems"
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    J. Agric. Food Chem. 50(23), 6725-6739.

  87. "The dual-specific active site of 7,8-diaminopelargonic acid synthase and the effect of the R391A mutation"
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    Biochemistry 41(42), 12582-12589.

  88. "The glucose-specific carrier of the Escherichia coli phosphotransferase system - Synthesis of selective inhibitors and inactivation studies"
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    Eur. J. Biochem. 269(20), 4969-4980.

  89. "Incorporation of an amide into 5-phosphonoalkyl-6-D- ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase"
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  90. "Prothrombinase assembly and S1 site occupation restore the catalytic activity of FXa impaired by mutation at the sodium- binding site"
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  91. "Oxidation of methoxyphenethylamines by cytochrome p450 2D6 - Analysis of rate-limiting steps"
    Guengerich, FP; Miller, GP; Hanna, IH; Sato, H; Martin, MV (2002)
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  92. "Mutational analysis of the base-flipping mechanism of uracil DNA glycosylase"
    Jiang, YL; Stivers, JT (2002)
    Biochemistry 41(37), 11236-11247.

  93. "Diversity in the oxidation of substrates by cytochrome P450 2D6: Lack of an obligatory role of aspartate 301 - Substrate electrostatic bonding"
    Guengerich, FP; Miller, GP; Hanna, IH; Martin, MV; Leger, S; Black, C; Chauret, N; Silva, JM; Trimble, LA; Yergey, JA; Nicoll-Griffith, DA (2002)
    Biochemistry 41(36), 11025-11034.

  94. "Effect of sequence polymorphism and drug resistance on two HIV- 1 Gag processing sites"
    Feher, A; Weber, IT; Bagossi, P; Boross, P; Mahalingam, B; Louis, JM; Copeland, TD; Torshin, IY; Harrison, RW; Tozser, J (2002)
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  95. "Design, synthesis, and evaluation of 6-carboxyalkyl and 6- phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase"
    Cushman, M; Yang, DL; Gerhardt, S; Huber, R; Fischer, M; Kis, K; Bacher, A (2002)
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  96. "Structural characterization of distinct alpha 3N and alpha 5 metal sites in the cyanobacterial zinc sensor SmtB"
    VanZile, ML; Chen, XH; Giedroc, DP (2002)
    Biochemistry 41(31), 9765-9775.

  97. "Allosteric negative regulation of smt O/P binding of the zinc sensor, SmtB, by metal ions: A coupled equilibrium analysis"
    VanZile, ML; Chen, XH; Giedroc, DP (2002)
    Biochemistry 41(31), 9776-9786.

  98. "Sugar recognition by the glucose and mannose permeases of Escherichia coli. Steady-state kinetics and inhibition studies"
    Garcia-Alles, LF; Zahn, A; Erni, B (2002)
    Biochemistry 41(31), 10077-10086.

  99. "Analysis of copper complex lability using Cu-64-equilibration techniques and free-ion selective radiotracer extraction"
    van Doornmalen, J; Wolterbeek, HT; de Goeij, JJM (2002)
    Anal. Chim. Acta 464(1), 141-152.

  100. "Metabolomics: quantification of intracellular metabolite dynamics"
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    Biomol. Eng. 19(1), 5-15.

  101. "High-level production of D-mannitol with membrane cell-recycle bioreactor"
    von Weymarn, N; Kiviharju, K; Leisola, M (2002)
    J. Ind. Microbiol. Biotechnol. 29(1), 44-49.

  102. "Nematode anticoagulant protein c2 reveals a site on factor Xa that is important for macromolecular substrate binding to human prothrombinase."
    Buddai, SK; Toulokhonova, L; Bergum, PW; Vlasuk, GP; Krishnaswamy, S (2002)
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  103. "Timing of epimerization and condensation reactions in nonribosomal peptide assembly lines: Kinetic analysis of phenylalanine activating elongation modules of tyrocidine synthetase B"
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    Biochemistry 41(29), 9184-9196.

  104. "Chemical transformation is not rate-limiting in the reaction catalyzed by Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase"
    Li, Y; Gong, YC; Shi, GB; Blaszczyk, J; Ji, XH; Yan, HG (2002)
    Biochemistry 41(27), 8777-8783.

  105. "F-1-ATPase changes its conformations upon phosphate release"
    Masaike, T; Muneyuki, E; Noji, H; Kinosita, K; Yoshida, M (2002)
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  106. "Elucidation of primary (alpha N-3) and vestigial (alpha(5)) heavy metal-binding sites in Staphylococcus aureus pI258 CadC: Evolutionary implications for metal ion selectivity of ArsR/SmtB metal sensor proteins"
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    J. Mol. Biol. 319(3), 685-701.

  107. "Reaction of aflatoxin B-1 oxidation products with lysine"
    Guengerich, FP; Arneson, KO; Williams, KM; Deng, ZW; Harris, TM (2002)
    Chem. Res. Toxicol. 15(6), 780-792.

  108. "C-2 epimer formation of tetrose, pentose and hexose sugars by xylose isomerase"
    Vuolanto, A; Pastinen, O; Schoemaker, HE; Leisola, M (2002)
    Biocatal. Biotransform. 20(4), 235-240.

  109. "The hsp70 chaperone DnaK is a secondary amide peptide bond cis- trans isomerase"
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    Nat. Struct. Biol. 9(6), 419-424.

  110. "Synthesis and self-association of an imine-containing m- phenylene ethynylene macrocycle"
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    J. Org. Chem. 67(11), 3548-3554.

  111. "Inhibition of uracil DNA glycosylase by an oxacarbenium ion mimic"
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    Biochemistry 41(22), 7116-7124.

  112. "The size-selective synthesis of folded oligomers by dynamic templation"
    Nishinaga, T; Tanatani, A; Oh, KC; Moore, JS (2002)
    J. Am. Chem. Soc. 124(21), 5934-5935.

  113. "Formation and structure of 1 : 1 complexes between aryl hydroxamic acids and vanadate at neutral pH"
    Bell, JH; Pratt, RF (2002)
    Inorg. Chem. 41(10), 2747-2753.

  114. "Selective inhibition of the C-domain of angiotensin I converting enzyme by bradykinin potentiating peptides"
    Cotton, J; Hayashi, MAF; Cuniasse, P; Vazeux, G; Ianzer, D; De Camargo, ACM; Dive, V (2002)
    Biochemistry 41(19), 6065-6071.

  115. "Characterization of the protrimer intermediate in the folding pathway of the interdigitated beta-helix tailspike protein"
    Benton, CB; King, J; Clark, PL (2002)
    Biochemistry 41(16), 5093-5103.

  116. "Hydrolysis of the 5 '-p-nitrophenyl ester of TMP by the proofreading exonuclease (epsilon) subunit of Escherichia coli DNA polymerase III"
    Hamdan, S; Bulloch, EM; Thompson, PR; Beck, JL; Yang, JY; Crowther, JA; Lilley, PE; Carr, PD; Ollis, DL; Brown, SE; Dixon, NE (2002)
    Biochemistry 41(16), 5266-5275.

  117. "Characterization of a metalloregulatory bismuth(III) site in Staphylococcus aureus pI258 CadC repressor"
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    Biochemistry 41(13), 4329-4338.

  119. "Candida guilliermondii grows on rare pentoses - implications for production of pure xylitol"
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    Biotechnol. Lett. 24(7), 507-510.

  120. "Identification of residues critical for activity of the wound- induced leucine aminopeptidase (LAP-A) of tomato"
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    Eur. J. Biochem. 269(6), 1630-1640.

  121. "The contribution of factor Xa to exosite-dependent substrate recognition by prothrombinase"
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  122. "Why OrfY? Characterization of MMOD, a long overlooked component of the soluble methane monooxygenase from Methylococcus capsulatus (Bath)"
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    J. Biol. Chem. 277(8), 5858-5865.

  123. "Molecular characterization of Ancylostoma inhibitors of coagulation factor Xa - Hookworm anticoagulant activity in vitro predicts parasite bloodfeeding in vivo"
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  124. "Concerted and stepwise dehydration mechanisms observed in wild- type and mutated Escherichia coli dTDP-glucose 4,6-dehydratase"
    Hegeman, AD; Gross, JW; Frey, PA (2002)
    Biochemistry 41(8), 2797-2804.

  125. "HIV-1 protease: Characterization of a catalytically competent enzyme-substrate intermediate"
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    Biochemistry 41(4), 1302-1307.

  126. "Foldamers as dynamic receptors: Probing the mechanism of molecular association between helical oligomers and rodlike ligands"
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    Angew. Chem.-Int. Edit. 41(2), 325-+.

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    Biochemistry 41(3), 1039-1050.

  128. "Inhibition of bacteriophage lambda protein phosphatase by organic and oxoanion inhibitors"
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    Biochemistry 41(3), 1051-1059.

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    Phys. Status Solidi A-Appl. Res. 188(4), 1345-1351.

  130. "Arp2/3 complex requires hydrolyzable ATP for nucleation of new actin filaments"
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    Proc. Natl. Acad. Sci. U. S. A. 98(26), 14871-14876.

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  132. "Inhibition of fructose-1,6-bisphosphatase by a new class of allosteric effectors"
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  133. "Cobalt(II) dioxygen carriers based on simple diamino ligands: Kinetic and ab initio studies"
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    Inorg. Chem. 42(25), 8214-8222.

  134. "Analysis of the kinetic mechanism of haloalkane conjugation by mammalian theta-class glutathione transferases"
    Guengerich, FP; McCormick, WA; Wheeler, JB (2003)
    Chem. Res. Toxicol. 16(11), 1493-1499.

  135. "Chimeric ribonuclease as a source of human adapter protein for targeted drug delivery"
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    Protein Eng. 16(10), 771-775.

  136. "Presteady state kinetic analysis of riboflavin synthase"
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    J. Biol. Chem. 278(48), 47700-47706.

  137. "DNA-binding and oligomerization studies of the manganese(II) metalloregulatory protein MntR from Bacillus subtilis"
    Lieser, SA; Davis, TC; Helmann, JD; Cohen, SM (2003)
    Biochemistry 42(43), 12634-12642.

  138. "Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis"
    Christenson, SD; Wu, WM; Spies, MA; Shen, B; Toney, MD (2003)
    Biochemistry 42(43), 12708-12718.

  139. "Reactivity of acrylate-terminated Au nanoparticles: Suppressed intramolecular catalysis and lack of cooperative effect"
    Koenig, S; Chechik, V (2003)
    Langmuir 19(22), 9511-9517.

  140. "Bacteriophage T4Dam (DNA-(adenine-N-6)-methyltransferase) - Evidence for two distinct stages of methylation under single turnover conditions"
    Malygin, EG; Lindstrom, WM; Zinoviev, VV; Evdokimov, AA; Schlagman, SL; Reich, NO; Hattman, S (2003)
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  141. "A model for the activation of plasma membrane calcium pump isoform 4b by calmodulin"
    Penheiter, AR; Bajzer, E; Filoteo, AG; Thorogate, R; Torok, K; Caride, AJ (2003)
    Biochemistry 42(41), 12115-12124.

  142. "Zinc fingers can act as Zn2+ sensors to regulate transcriptional activation domain function"
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    Embo J. 22(19), 5137-5146.

  143. "Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble epoxide hydrolase"
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    Biochemistry 42(40), 11762-11767.

  144. "Downstream DNA sequence effects on transcription elongation - Allosteric binding of nucleoside triphosphates facilitates translocation via a ratchet motion"
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  145. "Pre-steady-state and steady-state kinetic analysis of E-coli class I ribonucleotide reductase"
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    Biochemistry 42(34), 10071-10083.

  146. "On the substrate specificity of bacterial DD-peptidases: evidence from two series of peptidoglycan-mimetic peptides"
    Anderson, JW; Adediran, SA; Charlier, P; Nguyen-Disteche, M; Frere, JM; Nicholas, RA; Pratt, RF (2003)
    Biochem. J. 373(Pt. Part 3), 949-955.

  147. "Biochemical and functional analyses of the Mip protein: Influence of the N-terminal half and of peptidylprolyl isomerase activity on the virulence of Legionella pneumophila"
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  149. "Proflavine acts as a Rev inhibitor by targeting the high-affinity Rev binding site of the Rev responsive element of HIV-1"
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    Biochemistry 42(26), 8035-8046.

  150. "Steady-state and pre-steady-state kinetic analysis of halopropane conversion by a Rhodococcus haloalkane dehalogenase"
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    Biochemistry 42(26), 8047-8053.

  151. "Structural and thermodynamic dissection of specific mannan recognition by a carbohydrate binding module, TmCBM27"
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    Structure 11(6), 665-675.

  152. "New substrates for beta-lactam-recognizing enzymes: Aryl malonamates"
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    Biochemistry 42(22), 6719-6725.

  153. "Preparation and characterization of a 5 '-deazaFAD T491V NADPH-cytochrome P450 reductase"
    Zhang, HM; Gruenke, L; Saribas, AS; Im, SC; Shen, AL; Kasper, CB; Waskell, L (2003)
    Biochemistry 42(22), 6804-6813.

  154. "Mining HIV dynamics using independent component analysis"
    Draghici, S; Graziano, F; Kettoola, S; Sethi, I; Towfic, G (2003)
    Bioinformatics 19(8), 981-986.

  155. "Humanized docking system for assembly of targeting drug delivery complexes"
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  157. "Decorin binds fibrinogen in a Zn2+-dependent interaction"
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  158. "Enzyme I of the phosphotransferase system: Induced-fit protonation of the reaction transition state by Cys-502"
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    Biochemistry 42(16), 4744-4750.

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    Proc. Natl. Acad. Sci. U. S. A. 100(7), 3713-3718.

  160. "The metal-independent type IIs restriction enzyme BfiI is a dimer that binds two DNA sites but has only one catalytic centre"
    Lagunavicius, A; Sasnauskas, G; Halford, SE; Siksnys, V (2003)
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    Biochemistry 42(7), 1922-1929.

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    Biochemistry 42(6), 1529-1536.

  164. "Catalytic roles of arginine residues 82 and 92 of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: Site-directed mutagenesis and biochemical studies"
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    Biochemistry 42(6), 1581-1588.

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18Top of pageNext section
"Increase in fluorescence upon the hydrolysis of tyrosine peptides - application to proteinase assays"
Peranteau, AG; Kuzmic, P; Angell, Y; Garciaecheverria, C; Rich, DH (1995)
Anal. Biochem. 227(1), 242-245.
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"Radical reduction of C-Cl bonds in chlorofluoro ethers"
Liska, F; Fikar, J; Kuzmic, P (1993)
Collect. Czech. Chem. Commun. 58(3), 565-574.
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    Synthesis (17), 2627-2631.


20Top of pageNext section
"Stabilization of HIV proteinase dimer by bound substrate"
Kuzmic, P; Garciaecheverria, C; Rich, DH (1993)
Biochem. Biophys. Res. Commun. 194(1), 301-305.
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    Anal. Biochem. 227(1), 242-245.

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    Anal. Biochem. 237(2), 260-273.

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    Kuzmic, P; Peranteau, AG; GarciaEcheverria, C; Rich, DH (1996)
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  13. "Inhibition of HIV-1 protease by a subunit of didemnaketal A"
    Fan, XD; Flentke, GR; Rich, DH (1998)
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  15. "Use of a phosphotyrosine-antibody pair as a general detection method in homogeneous time-resolved fluorescence: Application to human immunodeficiency viral protease"
    Cummings, RT; McGovern, HM; Zheng, S; Park, YW; Hermes, JD (1999)
    Anal. Biochem. 269(1), 79-93.

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    Biochem. Cell Biol. 72(5-6), 175-181.


21Top of pageNext section
"A continuous spectrophotometric direct assay for peptidyl prolyl cis-trans-isomerases"
Garciaecheverria, C; Kofron, JL; Kuzmic, P; Rich, DH (1993)
Biochem. Biophys. Res. Commun. 191(1), 70-75.
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    Angew. Chem.-Int. Edit. Engl. 33(14), 1415-1436.

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    Garciaecheverria, C; Rich, DH (1995)
    Lett. Pept. Sci. 2(2), 77-82.

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    Biochemistry 34(41), 13594-13602.

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    Anal. Biochem. 252(2), 299-307.

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    Biopolymers 42(1), 49-60.

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    Bioorg. Med. Chem. Lett. 9(2), 295-300.

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22Top of pageNext section
"Kinetic assay for HIV proteinase subunit dissociation"
Kuzmic, P (1993)
Biochem. Biophys. Res. Commun. 191(3), 998-1003.
Citations
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    Kuzmic, P; Garciaecheverria, C; Rich, DH (1993)
    Biochem. Biophys. Res. Commun. 194(1), 301-305.

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    METHODS IN ENZYMOLOGY 241, 104-127.

  3. "Effect of ph and nonphysiological salt concentrations on human immunodeficiency virus-1 protease dimerization"
    Tyagi, SC; Simon, SR; Carter, CA (1994)
    Biochem. Cell Biol. 72(5-6), 175-181.

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    Biochemistry 33(1), 98-105.

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23Top of pageNext section
"Lithium-chloride perturbation of cis-trans peptide-bond equilibria - effect on conformational equilibria in cyclosporine-a and on time-dependent inhibition of cyclophilin"
Kofron, JL; Kuzmic, P; Kishore, V; Gemmecker, G; Fesik, SW; Rich, DH (1992)
J. Am. Chem. Soc. 114(7), 2670-2675.
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24Top of pageNext section
"Continuous fluorometric direct (uncoupled) assay for peptidyl prolyl cis-trans-isomerases"
Garciaecheverria, C; Kofron, JL; Kuzmic, P; Kishore, V; Rich, DH (1992)
J. Am. Chem. Soc. 114(7), 2758-2759.
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  2. "Prolyl isomerase - enzymatic catalysis of slow protein-folding reactions"
    Schmid, FX (1993)
    Annu. Rev. Biophys. Biomolec. Struct. 22, 123-143.

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  4. "A continuous spectrophotometric direct assay for peptidyl prolyl cis-trans-isomerases"
    Garciaecheverria, C; Kofron, JL; Kuzmic, P; Rich, DH (1993)
    Biochem. Biophys. Res. Commun. 191(1), 70-75.

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    ADVANCES IN PROTEIN CHEMISTRY 44, 25-66.

  6. "Peptidyl-prolyl cis/trans isomerases and their effectors"
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    Angew. Chem.-Int. Edit. Engl. 33(14), 1415-1436.

  7. "Calorimetric measurements of the complexation of cyclosporine- a, ascomycin, fujimycin, and rapamycin with lithium-chloride and with an immunophilin"
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    Helv. Chim. Acta 77(1), 291-305.

  8. "Kinetic-studies of papain - effect of p3' substituents and donor-acceptor pairs of intramolecularly quenched fluorogenic substrates"
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    Lett. Pept. Sci. 2(2), 77-82.

  9. "Kinetic-analysis of cyclophilin-catalyzed prolyl cis/trans isomerization by dynamic nmr-spectroscopy"
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    Biochemistry 34(41), 13594-13602.

  10. "Peptidylproline cis/trans isomerases"
    Galat, A; Metcalfe, SM (1995)
    Prog. Biophys. Mol. Biol. 63(1), 67-118.

  11. "Catalytic antibodies with peptidyl-prolyl cis-trans isomerase activity"
    YliKauhaluoma, JT; Ashley, JA; Lo, CHL; Coakley, J; Wirsching, P; Janda, KD (1996)
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  12. "Structure-function relationships in the FK506-binding protein (FKBP) family of peptidylprolyl cis-trans isomerases"
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    Biochem. J. 314(Pt. 2), 361-385.

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    Anal. Biochem. 252(2), 299-307.

  14. "Cyclophilin active site mutants have native prolyl isomerase activity with a protein substrate"
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    Schmid, FX (2002)
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25Top of pageNext section
"Mixtures of tight-binding enzyme-inhibitors - kinetic-analysis by a recursive rate-equation"
Kuzmic, P; Ng, KY; Heath, TD (1992)
Anal. Biochem. 200(1), 68-73.
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    Anal. Biochem. 205(1), 65-69.

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    Anal. Biochem. 221(2), 217-230.

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    Anal. Biochem. 267(1), 17-23.

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    Kuzmic, P; Hill, C; Kirtley, MP; Janc, JW (2003)
    Anal. Biochem. 319(2), 272-279.


26Top of pageNext section
"Fluorescence displacement method for the determination of receptor ligand-binding constants"
Kuzmic, P; Moss, ML; Kofron, JL; Rich, DH (1992)
Anal. Biochem. 205(1), 65-69.
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    Moss, ML; Palmer, RE; Kuzmic, P; Dunlap, BE; Henzel, W; Kofron, JL; Mellon, WS; Royer, CA; Rich, DH (1992)
    J. Biol. Chem. 267(31), 22054-22059.

  2. "Peptidyl-prolyl cis/trans isomerases and their effectors"
    Fischer, G (1994)
    Angew. Chem.-Int. Edit. Engl. 33(14), 1415-1436.

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    FEBS Lett. 360(2), 111-114.

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    Biochem. J. 331(Pt. 2), 571-575.

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    Kuzmic, P (1999)
    Anal. Biochem. 267(1), 17-23.

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    Biochemistry 44(24), 8721-8729.


27Top of pageNext section
"Identification of actin and hsp-70 as cyclosporine-a binding-proteins by photoaffinity-labeling and fluorescence displacement assays"
Moss, ML; Palmer, RE; Kuzmic, P; Dunlap, BE; Henzel, W; Kofron, JL; Mellon, WS; Royer, CA; Rich, DH (1992)
J. Biol. Chem. 267(31), 22054-22059.
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    Mol. Microbiol. 10(3), 445-456.

  2. "The fkb2 gene of saccharomyces-cerevisiae, encoding the immunosuppressant-binding protein fkbp-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic-reticulum"
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    Angew. Chem.-Int. Edit. Engl. 33(14), 1415-1436.

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    Biochem. Pharmacol. 47(8), 1435-1443.

  8. "Additive effects of calcipotriol and cyclosporine-a - from in- vitro experiments to in-vivo applications in the treatment of severe psoriasis"
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    Kidney Int. 50(5), 1483-1489.

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    Brain Res. 771(2), 203-212.

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    Anticancer Res. 18(3A), 1543-1547.

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    Biochim. Biophys. Acta-Biomembr. 1368(1), 7-18.

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    Itoh, H; Komatsuda, A; Wakui, H; Miura, AB; Tashima, Y (1999)
    J. Biol. Chem. 274(49), 35147-35151.

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    Biochem. Biophys. Res. Commun. 269(2), 464-469.

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    Clin. Dermatol. 17(6), 641-647.

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    Nephron Exp. Nephrol 94(3), E94-E102.

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    Life Sci. 73(4), 381-392.

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28Top of pageNext section
"Determination of kinetic constants for peptidyl prolyl cis trans isomerases by an improved spectrophotometric assay"
Kofron, JL; Kuzmic, P; Kishore, V; Colonbonilla, E; Rich, DH (1991)
Biochemistry 30(25), 6127-6134.
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    Biochemistry 30(44), 10818-10818.

  2. "Crystal-structure of recombinant human t-cell cyclophilin-A at 2.5-a resolution"
    Ke, HM; Zydowsky, LD; Liu, J; Walsh, CT (1991)
    Proc. Natl. Acad. Sci. U. S. A. 88(21), 9483-9487.

  3. "Streptomycetes possess peptidyl-prolyl cis-trans isomerases that strongly resemble cyclophilins from eukaryotic organisms"
    Pahl, A; Uhlein, M; Bang, H; Schlumbohm, W; Keller, U (1992)
    Mol. Microbiol. 6(23), 3551-3558.

  4. "Identification of actin and hsp-70 as cyclosporine-a binding- proteins by photoaffinity-labeling and fluorescence displacement assays"
    Moss, ML; Palmer, RE; Kuzmic, P; Dunlap, BE; Henzel, W; Kofron, JL; Mellon, WS; Royer, CA; Rich, DH (1992)
    J. Biol. Chem. 267(31), 22054-22059.

  5. "Active-site mutants of human cyclophilin-A separate peptidyl- prolyl isomerase activity from cyclosporine-a binding and calcineurin inhibition"
    Zydowsky, LD; Etzkorn, FA; Chang, HY; Ferguson, SB; Stolz, LA; Ho, SI; Walsh, CT (1992)
    Protein Sci. 1(9), 1092-1099.

  6. "Proline isomerases at the crossroads of protein folding, signal transduction, and immunosuppression"
    Heitman, J; Movva, NR; Hall, MN (1992)
    4(5), 448-460.

  7. "Enzymatic catalysis of prolyl isomerization in an unfolding protein"
    Mucke, M; Schmid, FX (1992)
    Biochemistry 31(34), 7848-7854.

  8. "Fluorescence displacement method for the determination of receptor ligand-binding constants"
    Kuzmic, P; Moss, ML; Kofron, JL; Rich, DH (1992)
    Anal. Biochem. 205(1), 65-69.

  9. "Immunophilin structure - a template for immunosuppressive drug design"
    Walkinshaw, MD; Kallen, J; Weber, HP; Widmer, A; Widmer, H; Zurini, M (1992)
    Transplant. Proc. 24(4), 8-13.

  10. "Natural-products as probes of cellular function - studies of immunophilins"
    Rosen, MK; Schreiber, SL (1992)
    Angew. Chem.-Int. Edit. Engl. 31(4), 384-400.

  11. "Cyclosporine-a, the cyclophilin class of peptidylprolyl isomerases, and blockade of t-cell signal transduction"
    Walsh, CT; Zydowsky, LD; Mckeon, FD (1992)
    J. Biol. Chem. 267(19), 13115-13118.

  12. "Solvent effects on the energetics of prolyl peptide-bond isomerization"
    Eberhardt, ES; Loh, SN; Hinck, AP; Raines, RT (1992)
    J. Am. Chem. Soc. 114(13), 5437-5439.

  13. "Purification and n-terminal sequencing of peptidyl-prolyl cis- trans-isomerase from rat-liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin"
    Connern, CP; Halestrap, AP (1992)
    Biochem. J. 284(Pt. 2), 381-385.

  14. "Mip protein of legionella-pneumophila exhibits peptidyl-prolyl- cis trans isomerase (pplase) activity"
    Fischer, G; Bang, H; Ludwig, B; Mann, K; Hacker, J (1992)
    Mol. Microbiol. 6(10), 1375-1383.

  15. "Mechanistic studies of enzymatic and nonenzymic prolyl cis- trans isomerization"
    Harrison, RK; Stein, RL (1992)
    J. Am. Chem. Soc. 114(9), 3464-3471.

  16. "A quantitative assay for the determination of proline and hydroxyproline by capillary electrophoresis"
    Guzman, NA; Moschera, J; Iqbal, K; Malick, AW (1992)
    J. Liq. Chromatogr. 15(6-7), 1163-1177.

  17. "The x-ray structure of a tetrapeptide bound to the active-site of human cyclophilin-A"
    Kallen, J; Walkinshaw, MD (1992)
    FEBS Lett. 300(3), 286-290.

  18. "Cyclosporine-a, fk-506, and rapamycin - pharmacological probes of lymphocyte signal transduction"
    Sigal, NH; Dumont, FJ (1992)
    Annu. Rev. Immunol. 10, 519-560.

  19. "Lithium-chloride perturbation of cis-trans peptide-bond equilibria - effect on conformational equilibria in cyclosporine-a and on time-dependent inhibition of cyclophilin"
    Kofron, JL; Kuzmic, P; Kishore, V; Gemmecker, G; Fesik, SW; Rich, DH (1992)
    J. Am. Chem. Soc. 114(7), 2670-2675.

  20. "Continuous fluorometric direct (uncoupled) assay for peptidyl prolyl cis-trans-isomerases"
    Garciaecheverria, C; Kofron, JL; Kuzmic, P; Kishore, V; Rich, DH (1992)
    J. Am. Chem. Soc. 114(7), 2758-2759.

  21. "Ppiase catalysis by human fk506-binding protein proceeds through a conformational twist mechanism"
    Park, ST; Aldape, RA; Futer, O; Decenzo, MT; Livingston, DJ (1992)
    J. Biol. Chem. 267(5), 3316-3324.

  22. "A mechanism for rotamase catalysis by the fk506 binding-protein (fkbp)"
    Fischer, S; Michnick, S; Karplus, M (1993)
    Biochemistry 32(50), 13830-13837.

  23. "Conformationally defined analogs of prolylamides - trans-prolyl peptidomimetics"
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    J. Org. Chem. 58(24), 6609-6613.

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    Orozco, M; Tiradorives, J; Jorgensen, WL (1993)
    Biochemistry 32(47), 12864-12874.

  25. "Distribution characteristics of immunosuppressants fk506 and cyclosporine-a in the blood compartment"
    Takada, K; Katayama, N; Kiriyama, A; Usuda, H (1993)
    Biopharm. Drug Dispos. 14(8), 659-671.

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    Luque, FJ; Orozco, M (1993)
    J. Org. Chem. 58(23), 6397-6405.

  27. "Immunophilins - structure-function relationship and possible role in microbial pathogenicity"
    Hacker, J; Fischer, G (1993)
    Mol. Microbiol. 10(3), 445-456.

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    Holt, DA; Luengo, JI; Yamashita, DS; Oh, HJ; Konialian, AL; Yen, HK; Rozamus, LW; Brandt, M; Bossard, MJ; Levy, MA; Eggleston, DS; Liang, J; Schultz, LW; Stout, TJ; Clardy, J (1993)
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    Science 262(5131), 248-250.

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    Eur. J. Biochem. 216(3), 689-707.

  31. "Kinetic effect of the substrate instability on the michaelis- menten mechanism"
    Delsolo, CG; Castellanos, RV; Canovas, FG; Havsteen, BH (1993)
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  32. "Prolyl isomerases catalyze antibody folding in-vitro"
    Lilie, H; Lang, K; Rudolph, R; Buchner, J (1993)
    Protein Sci. 2(9), 1490-1496.

  33. "Kinetic-analysis of a michaelis-menten mechanism with an unstable substrate"
    Varon, R; Valero, E; Garridodelsolo, C; Garciacanovas, F; Havsteen, BH (1993)
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  34. "Structural studies of complexed fk-506 binding-protein"
    Clardy, J (1993)
    Ann. N.Y. Acad. Sci. 685, 37-45.

  35. "Prolyl isomerase - enzymatic catalysis of slow protein-folding reactions"
    Schmid, FX (1993)
    Annu. Rev. Biophys. Biomolec. Struct. 22, 123-143.

  36. "A nonimmunosuppressive triene-modified rapamycin analog is a potent inhibitor of peptidyl-prolyl cis-trans isomerase"
    Ocain, TD; Longhi, D; Steffan, RJ; Caccese, RG; Sehgal, SN (1993)
    Biochem. Biophys. Res. Commun. 192(3), 1340-1346.

  37. "Crystal-structure of cyclophilin-A complexed with substrate ala-pro suggests a solvent-assisted mechanism of cis-trans isomerization"
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    J. Pept. Res. 65(3), 364-374.

  245. "Effects of cyclophilin A on cell proliferation and gene expressions in human vascular smooth muscle cells and endothelial cells"
    Yang, H; Li, M; Chai, H; Yan, SY; Lin, P; Lumsden, AB; Yao, QZ; Chen, CY (2005)
    J. Surg. Res. 123(2), 312-319.

  246. "A Plasmodium falciparum FK506-binding protein (FKBP) with peptidyl-prolyl cis-trans isomerase and chaperone activities"
    Monaghan, P; Bell, A (2005)
    Mol. Biochem. Parasitol. 139(2), 185-195.

  247. "Structural determinants of the anti-HIV activity of a CCR5 antagonist derived from Toxoplasma gondii"
    Yarovinsky, F; Andersen, JF; King, LR; Caspar, P; Aliberti, J; Golding, H; Sher, A (2004)
    J. Biol. Chem. 279(51), 53635-53642.


29Top of pageNext section
"Long-range electrostatic effects in pepsin catalysis"
Kuzmic, P; Sun, CQ; Zhao, ZC; Rich, DH (1991)
Tetrahedron 47(14-15), 2519-2534.
Citations
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    Ciarkowski, J; Oldziej, S (1993)
    Eur. Biophys. J. Biophys. Lett. 22(3), 207-212.

  2. "Substrates and inhibitors of human T-cell leukemia virus type I protease"
    Ding, YS; Rich, DH; Ikeda, RA (1998)
    Biochemistry 37(50), 17514-17518.

  3. "Aspartic protease inhibitors: Expedient synthesis of 2- substituted statines"
    Travins, JM; Bursavich, MG; Veber, DF; Rich, DH (2001)
    Org. Lett. 3(17), 2725-2728.

  4. "Role of charged residues in the catalytic mechanism of hepatitis C virus NS3 protease: Electrostatic precollision guidance and transition-state stabilization"
    Koch, U; Biasiol, G; Brunetti, M; Fattori, D; Pallaoro, M; Steinkuhler, C (2001)
    Biochemistry 40(3), 631-640.

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    Bursavich, MG; Rich, DH (2002)
    J. Med. Chem. 45(3), 541-558.

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    Dunn, BM (2002)
    Chem. Rev. 102(12), 4431-4458.


30Top of pageNext section
"Substituent effects in aromatic photochemistry. UV irradiation of 3,4-dimethoxybenzonitrile and 3,4-dimethoxyacetophenone in the presence of inorganic anions"
Kuzmic, P; Soucek, M (1987)
Collect. Czech. Chem. Commun. 52, 980-988.
Citations
  1. "Sodium bis(trimethylsilyl)amide in the "one-flask" transformation of aromatic esters to nitriles"
    Hwu, JR; Hsu, CH; Wong, FF; Chung, CS; Hakimelahi, GH (1998)
    Synthesis (3), 329-332.

  2. "Photochemical cyanation of aromatic compounds"
    Konstantinov, AD; Bunce, NJ (1999)
    J. Photochem. Photobiol. A-Chem. 125(1-3), 63-71.


31Top of pageNext section
"Photoreaction of N-butyl 3,4-dimethoxy-6-nitrobenzamide with butylamine. A model study for lysine-directed photoaffinity labeling"
Kuzmic, P; Pavlickova, L; Soucek, M (1987)
Collect. Czech. Chem. Commun. 52, 1780-1785.
Citations
  1. "Chemical reagents in photoaffinity-labeling"
    Fleming, SA (1995)
    Tetrahedron 51(46), 12479-12520.

  2. "Side reactions during photochemical cleavage of an alpha- methyl-6-nitroveratryl-based photolabile linker"
    Rinnova, M; Novakova, M; Kasicka, V; Jiracek, J (2000)
    J. Pept. Sci. 6(8), 355-365.


32Top of pageNext section
"Photo-cyanation of 3,4-di-methoxy-1-nitro-benzene. A quantitative study"
Kuzmic, P; Soucek, M (1986)
Collect. Czech. Chem. Commun. 51, 358-367.
Citations
  1. "Photochemical cyanation of aromatic compounds"
    Konstantinov, AD; Bunce, NJ (1999)
    J. Photochem. Photobiol. A-Chem. 125(1-3), 63-71.


33Top of pageNext section
"Photochemical hydrolysis of some nitrophenyl acetates"
Kuzmic, P; Pavlickova, L; Soucek, M (1986)
Collect. Czech. Chem. Commun. 51, 1293-1300.
Citations
  1. "Toward the development of new photolabile protecting groups that can rapidly release bioactive compounds upon photolysis with visible light"
    Banerjee, A; Grewer, C; Ramakrishnan, L; Jager, J; Gameiro, A; Breitinger, HGA; Gee, KR; Carpenter, BK; Hess, GP (2003)
    J. Org. Chem. 68(22), 8361-8367.

  2. "Caging proteins through unnatural amino acid mutagenesis"
    Petersson, EJ; Brandt, GS; Zacharias, NM; Dougherty, DA; Lester, HA (2003)
    Methods Enzymol. 360, 258-273.

  3. "A protecting group for carboxylic acids that can be photolyzed by visible light"
    Shembekar, VR; Chen, YL; Carpenter, BK; Hess, GP (2005)
    Biochemistry 44(19), 7107-7114.


34Top of pageNext section
"Photoreaction of 3,4-dimethoxy-1-nitrobenzene with butylamine. A pH dependence of regioselectivity"
Kuzmic, P; Pavlickova, L; Velek, J; Soucek, M (1986)
Collect. Czech. Chem. Commun. 51, 1665-1670.
Citations
  1. "Singlet-triplet mechanistic duality in the photosubstitution of nitrophenyl ethers with ethyl glycinate - the role of single electron-transfer"
    Marquet, J; Cantos, A; Morenomanas, M; Cayon, E; Gallardo, I (1992)
    Tetrahedron 48(7), 1333-1342.

  2. "Side reactions during photochemical cleavage of an alpha- methyl-6-nitroveratryl-based photolabile linker"
    Rinnova, M; Novakova, M; Kasicka, V; Jiracek, J (2000)
    J. Pept. Sci. 6(8), 355-365.


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