Figure 2

Inhibition of human mast-cell tryptase by APC-1390. The dashed curve was generated according to the Morrison equation (1) [11], by using the automatically generated initial estimate for the apparent inhibition constant, K = 66.3 pM. The solid curve was generated by using the best least-squares fit value of the inhibition constant, K = 59.5 ± 6.7 pM.