Features
Benefits
System Requirements

Program PlateKi for Windows-NT/9x/2000/XP is currently used in leading pharmaceutical research laboratories to determine "tight-binding"or "classical" inhibition constants from raw plate-reader data. Associated IC₅₀ values are also determined for compatibility with most corporate databases.

Features

• Automatic model selection in fitting the reaction progress curves (straight line, quadratic parabola, first or second degree exponential).
• Automatic initial estimate of the inhibition constant .
• Optional robust regression with automatic exclusion of outliers .
• Determination of nonsymmetrical confidence intervals for model parameters according to the profile-t method (Bates & Watts, 1988).
• Fitting of dose-response curves either to the Morrison equation for tight binding or to the four-parameter logistic equation.

Benefits

• High processing speed (approximately 100 milliseconds per inhibition constant, including progress curve analysis).
• Outlier exclusion minimizes labor and removes subjective bias.
• Can be used for secondary in-vitro screening of purified enzymes, or in cell-based assays.
• Summary output file can be imported into Excel and/or corporate databases.

System Requirements

PlateKi for Windows

• Intel® Pentium® III or Celeron® class 800 MHz or faster processor
• Microsoft Windows® XP (SP1) or 2000 (SP2)
• 128 MB RAM
• 20 MB Hard Disk Space
• Ethernet Network Interface Card required for license activation⁽¹⁾
• CD/DVD-ROM drive required for software installation⁽²⁾

⁽¹⁾ The Network Interface Card is used to compute a unique "Computer ID", tied to a particular PlateKi license. Essentially the "Computer ID" required for license activation is an encrypted Media Access Control (MAC address) associated with the given Network Card.

⁽²⁾ CD/DVD-ROM is not required if the software is being installed by using the downloadable installer file plateki-install.zip.