BioKin Ltd. provides consulting services and custom software design for pharmaceutical research laboratories. Typically the product of each consulting agreement is a highly specialized software program derived from the program DYNAFIT [P. Kuzmic (1996) Anal. Biochem. 237, 260-273]. Each specialized program

• is seamlessly integrated into the software environment of the given laboratory (operating systems - Mac / Windows / Unix)
• conforms to the nature of the biochemical target (kinetic mechanism of inhibition)
• accepts as input primary datafiles obtained on the given hardware (plate readers - Molecular Devices; robots - Hewlett-Packard)
• produces text or graphical output in the specified format (databases - Oracle / FileMaker)

Such specialized software is most profitably used in the screening phase of the drug discovery project, when the inhibition mechanism already has been established by using DYNAFIT. In special cases (e.g., when the reaction mechanism is simple competitive inhibition) the high-throughput screening software can be used to process plate reader data for 100-200 enzyme inhibitors a week.

In these simple cases of inhibition mechanisms, the speed of screening is completely determined by the experimental protocol, while the computation times are virtually neglible. A typical plate-reader datafile containing dose-response data for 6 inhibitors can be processed completely in less than one minute. Demonstration programs are available upon request.

Sample consulting contracts are available. Please click on the hyperlinks in the navigation bar on the left.