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TN201501

History of the "Morrison Equation"

History, variants and usage of the "Morrison equation" in enzyme inhibition kinetics

BioKin Technical Note TN-2015-01

Petr Kuzmic
BioKin Ltd.
Draft - Rev. 1.03 - January 22, 2015

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Abstract

The term "Morrison equation" has varied meaning in the works published by different researchers in enzyme kinetics. This technical note summarizes the historical variants and predecessors of the "Morrison equation" as published by Ackermann & Potter (1949), Morrison (1969), Cha (1975) and Greco & Hakala (1979). Attention is also given to relatively recent textbook treatments by Copeland (2010, 2013). The disparate mathematical formalisms are first converted to a unified algebraic notation and then compared with respect the type of experimental data (i.e., either absolute or fractional rates) that are required to utilize the given algebraic form. A comparison is also made with respect to the implied inhibition mechanism, if any, as well as the number and type of optimized model parameters in nonlinear regression.

Keywords

enzyme kinetics; mathematics; inhibition; tight binding; Morrison Equation

How to Cite

Kuzmic, P. (2015) History, variants and usage of the "Morrison equation" in enzyme inhibition kinetics, BioKin Technical Note TN-2015-01, BioKin Ltd., Watertown MA, [Online] www.biokin.com/TN/2015/01

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Sat Apr 20 18:22:31 2019